• FreeAdvice has a new Terms of Service and Privacy Policy, effective May 25, 2018.
    By continuing to use this site, you are consenting to our Terms of Service and use of cookies.

health supplement caused coma

Accident - Bankruptcy - Criminal Law / DUI - Business - Consumer - Employment - Family - Immigration - Real Estate - Tax - Traffic - Wills   Please click a topic or scroll down for more.

Status
Not open for further replies.

mtmon

Member
re:

Know what they require that you test for? Micotoxins. E. coli. A few other things that are irrelevant to the discussion. If your coma wasn't induced by one of those things... And even if it WAS induced by one of those things, you'd have to prove that the company NEW their numbers were outside the GAS range, and sold the product anyway.

You chose to take a supplement that is GAS (generally accepted as safe), and experienced a negative outcome. It's not necessarily anyone's FAULT, and there is not likely to be a lawsuit here.

What about the contradictory instances like Bath Salts, GHB, L-Tryptophan, DMT, ephedrine, numerous testosterone supplements, Phen-Fen, etc.?
 


stealth2

Under the Radar Member
Unprecedented case of kidney failure coma + severe prolonged seizure directly following the ingestion of largely non-researched product which is substantiated to target brain (however). Substance can easily be interpreted by anyone familiar with the drug as a potentially useful in suicide or homicide. Anyone on the stand wants to argue, take two or more teaspoonfuls.
Respectfully submitted.

Why would you even think to take a substance that is largely non-researched? I mean - that's just dumb.
 

CJane

Senior Member
What about the contradictory instances like Bath Salts

The "zombie drug" bath salts? You know that they're not ACTUALLY bath salts like you'd buy in the store and use in your bathtub, right? That "bath salts" is the street name? Also, that even if they WERE actual bath salts, this would fo' sho' and certain be considered off label use?

Everything else you listed has a legitimate purpose, and when used "off label", may have unforeseen side-effects. Doesn't mean that you're going to win the lawsuit lottery when you choose to have botulism injected into your face, and it goes horribly wrong.
 

Proserpina

Senior Member
What about the contradictory instances like Bath Salts, GHB, L-Tryptophan, DMT, ephedrine, numerous testosterone supplements, Phen-Fen, etc.?



Given that Phen-Fen was an FDA approved drug, it's completely irrelevant to your little discussion.

Next?
 

OHRoadwarrior

Senior Member
L-Tryptophan was taken off the market supposedly due to bad shipment from overseas. Coincidentally, a drug manufacturer had a substitute product they had just released.:cool: It is back on the market BTW

Ephedrine was only dangerous if you ignored the dosage. In fact, I used to put it in my babies juice bottle to clear up asthma attacks. The occasional person thought if a limit of 6 per day worked great, 18 per day would produce unbelievable results and had a heart attack. That was the supposed reason for removing it from the market. Mysteriously, if you look at the law, it banned ephedra and severely limited psuedo-ephedrine. Interesting that both were being used in home drug labs.
 

mtmon

Member
re:

Those other substances are drugs, not supplements. Big difference.

Actually, most of those I listed are on the FDA's website under the heading Banned Supplements...Go figure. And Phenibut is often retailed in other countries clearly under "Drug." It is very close in it's molecule structure, mechanism of action, and effects to GHB. GHB, as with some of the other compounds, was sold in health food stores as a dietary supplement before it was pulled due to it's very hazardous nature. Later, it was repackaged as a prescription only controlled DRUG. (So, which is it?!) This happens to be the case with numerous other "dietary-aides", "health-foods","supplements", "natural"...substances deemed unsafe as OTC and repackaged as "prescription drugs."
OK, PLEASE don't bother to post exaggerated claims with demeaning inflections, which hold zero credit. This is deconstructive to the discussion taking place here. Thanks!
 
Last edited:

Silverplum

Senior Member
Actually, most of those I listed are on the FDA's website under the heading Banned Supplements...Go figure. And Phenibut is often retailed in other countries clearly under "Drug." It is very close in it's molecule structure, mechanism of action, and effects to GHB. GHB, as with some of the other compounds, was sold in health food stores as a dietary supplement before it was pulled due to it's very hazardous nature. Later, it was repackaged as a prescription only controlled DRUG. (So, which is it?!) This happens to be the case with numerous other "dietary-aides", "health-foods","supplements", "natural"...substances deemed unsafe as OTC and repackaged as "prescription drugs."
OK, PLEASE don't bother to post exaggerated claims with demeaning inflections, which hold zero credit. This is deconstructive to the discussion taking place here. Thanks!

We can all just make up our own words now? Because that would just be so much easier...for other people.

:cool:
 

tranquility

Senior Member
When young, I read a book called "From Chocolate to Morphine". It pointed out the fact that determining what a "drug" is can be difficult at best. By most any definition of "drug", we would include many things one would not otherwise consider. Many want to classify sugar a drug. Creatine is a naturally occurring substance produced by our bodies. Athletes have often eaten foods rich in the acid, to increase ATP which is essentially the "match sticks" that fuel muscle contractions, in the hope of improving performance for high-intensity, short-time activity. Things like steak, fish and other meats. Others take a supplement containing bioavailable creatine.

When does it become a "drug"?

We could go on with many substances, but the key is knowing the risks and rewards of anything you put in your body. You can't focus on the category it is placed in, you have to focus on what it does.

Legally, we might define a drug as:
The FD&C Act defines drugs, in part, by their intended use, as "articles intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease" and "articles (other than food) intended to affect the structure or any function of the body of man or other animals" [FD&C Act, sec. 201(g)(1)].

In this case, unless Phenibut is considered a food (Or, perhaps, a device.), it's a drug. Well, at least legally. However, I'm not sure how that distinction means anything here or why there is a debate on the matter.
 

mtmon

Member
re:

L-Tryptophan was taken off the market supposedly due to bad shipment from overseas. Coincidentally, a drug manufacturer had a substitute product they had just released.:cool: It is back on the market BTW

Ephedrine was only dangerous if you ignored the dosage. In fact, I used to put it in my babies juice bottle to clear up asthma attacks. The occasional person thought if a limit of 6 per day worked great, 18 per day would produce unbelievable results and had a heart attack. That was the supposed reason for removing it from the market. Mysteriously, if you look at the law, it banned ephedra and severely limited psuedo-ephedrine. Interesting that both were being used in home drug labs.

PLEASE READ: Will suitably vituperate above comments. (On a side note
Wide spread public information and insight:

In the fall of 1989, the FDA recalled L-Tryptophan, an amino acid nutritional supplement, stating that it caused a rare and deadly flu-like condition (Eosinophilia-Myalgia Syndrome — EMS)

On March 22, 1990, the FDA banned the public sale dietary of L-Tryptophan completely. On March 26, 1990, Newsweek featured a lead article praising the virtues of the anti-depressant drug Prozac. Its multi-color cover displayed a floating, gigantic green and white capsule of Prozac with the caption: “Prozac: A Breakthrough Drug for Depression.”

The fact that the FDA ban of L-Tryptophan and the Newsweek Prozac cover story occurred within four days of each other went unnoticed by both the media and the public. Yet, to those who understand the effective properties of L-Tryptophan and Prozac, the concurrence seems “unbelievably coincidental.” The link here is the brain neurotransmitter serotonin — a biochemical nerve signal conductor. The action of Prozac and L-Tryptophan are both involved with serotonin, but in totally different ways.

Elevated levels of serotonin in the body often result in the relief of depression, as well as substantial reduction in pain sensitivity, anxiety and stress. Prozac, as well as other new anti-depressant drugs such as Paxil and Zoloft, attempt to enhance levels of serotonin by working on whatever amounts of it already exist in the body (these drugs are known as selective serotonin reuptake inhibitors). None of these drugs, however, produce serotonin. In contrast, ingested L-Tryptophan acts to produce serotonin, even in individuals who generate little serotonin of their own. The most effective way to elevate levels of serotonin would be to use a serotonin producer rather than a serotonin enhancer.

Present FDA public policy maintains that L-Tryptophan is an untested, unapproved and hazardous drug. The analytical work done a few years ago by the Centers for Disease Control and the Mayo Clinic, research which traced the fall 1989 outbreak of the serious flu-like condition to contaminants found in batches of L-Tryptophan made by the Japanese company Showa Denko, has not convinced the FDA to allow L-Tryptophan back on the market. This decision is based primarily on the research of FDA and NIMH scientists who state that L-Tryptophan itself, irrespective of contaminants, is a dangerous substance. Other university-based research scientists disagree with these findings.

The public availability of L-Tryptophan is too important an issue only to be argued and shrouded within a scientific debate that remains, ultimately, mystifying to the vast majority of Americans. There are many obvious facts worthy of public attention, and public concern. For example, consider the following:

On February 9, 1993, a United States government patent (#5185157) was issued to use L-Tryptophan to treat, and cure EMS, the very same deadly flu-like condition which prompted the FDA to take L-Tryptophan off the market in 1989.

Notwithstanding its public ban and import alert on L-Tryptophan, the FDA today allows Ajinomoto U.S.A. the right to import from Japan human-use L-Tryptophan. Distributed from the Ajinomoto plant in Raleigh, North Carolina, the L-Tryptophan is then sold to, and through, a network of compounding pharmacies across the United States. Purchased by individuals only under a physician's order, L-Tryptophan emerges as a new prescription drug in the serotonin marketplace; one hundred 500 mg capsules cost about $75 — approximately five times more than if they were sold as a dietary supplement.

Since the FDA holds the political mandate and power of a public regulatory agency established, ostensibly, to protect people from raw corporate interests in drug production and distribution, the actions of the FDA in concert with Ajinomoto U.S.A. are illuminating. By publicly banning L-Tryptophan from its dietary supplement status and price, while allowing L-Tryptophan to be sold as a high-priced prescription drug, the naked duplicity of FDA L-Tryptophan policy is revealed.

During and after the 1989 EMS outbreak, the FDA did not totally ban the use of L-Tryptophan in humans — then, as today, the FDA has granted the pharmaceutical industry the protected right to use L-Tryptophan in hospital settings. Manufactured by Abbott Laboratories, the amino acid injectable solutions Aminosyn and Aminosyn II contain as much as 200 mg of L-Tryptophan. (Moreover, L-Tryptophan has never been removed from baby food produced and sold within the United States.)

While the FDA has banned the public sale and use of safe, non-contaminated, dietary supplement L-Tryptophan for people, the United States Department of Agriculture still sanctions the legal sale and use of non-contaminated L-Tryptophan for animals. Today, as in the past, feed grade L-Tryptophan continues to be used as a nutritional and bulk feed additive by the commercial hog and chicken farming industry. Additionally, L-Tryptophan is now available for use by veterinarians in caring for horses and pets. Outside of the United States, in countries such as Canada, the Netherlands, Germany, England, and others, L-Tryptophan is widely used. Nowhere, have any serious or widespread health problems occurred.

At bottom, the FDA public ban of safe, non-contaminated L-Tryptophan is uneven, expensive, and biased in favor of the pharmaceutical industry. The FDA proscription effectively awards billions of dollars in profits to pharmaceutical companies and their suppliers in the same proportion as it adds billions of unnecessary dollars to the nation's already bloated health care expenditures.

EPHEDRINE/EPHEDRA--

References

MayoClinic.com: Ephedra (Ephedra sinica) / Ma Huang
National Center for Complementary and Alternative Medicine: Ephedra

Side Effects:

There are many different side effects associated with taking supplements or products that contain ephedrine, the National Center of Complementary and Alternative Medicine explains. Consuming ephedrine can cause anxiety, dry mouth, stomach irritation, kidney stones or headache. Ephedrine can also result in nausea, restlessness and sleep problems, and it can trigger psychosis in some patients. Products containing ephedrine should not be taken by pregnant or lactating women, due to the potential for ephedrine to cross the placenta or get into breast milk.

Ephedrine can cause a wide variety of other unwanted side effects. According to Drug Information Online, ephedrine may affect affect blood sugar and interact with certain diabetes medications. Common side effects include vertigo, sweating, insomnia and nervousness.

Because diabetes increases the risk for heart disease, diabetic patients who take ephedrine should be aware of the drug's cardiovascular risks, such as arrhythmia and tachycardia, according to Rx List.

LONG TERM EFFECTS ALSO INCLUDE:
Nerve Damage

Gastrointestinal Problems

Potassium Imbalance

Emotional Disturbance

Increased Blood Pressure...

USER COMMENTS--
Sean Hoey · Angel at Works for God
Iv been taking eph.eca and pure ephedrine for 3half years.i train 6days a wk I don't go to the doctor much but I have most of the systems iv read about.i would say id be addicted to the stuff..im34 and hsve 4 kids can the damaged be reversed the memory loss is the worst.


Ephedra Ban

In 2004, dietary supplements containing ephedra were banned in the United States by the Food and Drug Administration following studies that showed an unreasonable risk of serious side effects, including fatal cardiovascular problems. According to the National Center for Complementary and Alternative Medicine, this ban does not extend to traditional Chinese remedies or teas that contain ephedrine if they are regulated like conventional foods. Chemically synthesized ephedrine may still be used to treat asthma and other conditions that cause nasal congestion or wheezing, according to Drugs.com.
Supplement Risks

The poor regulation of dietary supplements is a cause of concern for any that are purported to contain ephedrine, as they are likely to be from a less-than-reputable source. A compound, such as ephedrine, being listed on a label does not necessarily mean that the compound is actually present in the supplement. Often, the chemical composition of dietary supplements does not match the ingredients on the label. Consuming supplements that claim to have ephedrine could result in your inadvertent consumption of contaminants that put your health at risk.

Read more: http://www.livestrong.com/article/392153-ephedrine-dangers/#ixzz2btGBjR7b
 

mtmon

Member
re:

If it's not FDA approved, you might have trouble a) proving that was the cause and b) getting an attorney to take on the case.

As with any supplement, take at your own risk.

It is not FDA approved:

How does Phenibut work?
Phenibut is similar to the brain chemical called GABA. Phenibut has not been studied in humans. Research in animals shows that it might decrease anxiety and have other effects on the body. There is not enough information to know if it has any beneficial effects in humans. (I wonder if there are any Russian studies, noting its reported use by cosmonauts. It's a controlled substance there...other countries?)

Are there safety concerns?
There is not enough information to know if phenibut is safe. It has not been studied in humans. (It is very similar in action, in molecule structure, its target cells, and side effects to the compound GHB)**explore information regarding this particular compound, I feel it is VERY pertinent/comparable to questions referential to Phenibut.For example, several analogs and precursors to GHB have surfaced and been systematically banned w/extreme prejudice. Interesting is the fact that Peter Jennings did a TV news expose touting GHB as a "miracle nutrient!"
The FDA's national press release of 8 November 1990, which declared that GHB was a drug, marked the beginning of a series of law-enforcement actions and court cases. At that time, GHB was being sold in health food stores on an over-the-counter basis. With that press release, the FDA and federal and local police began to threaten businesses with legal prosecution for selling GHB. They arrested business owners and told them that they would be prosecuted unless they testified against their wholesale suppliers.

The FDA succeeded in driving the GHB business underground. They began legal proceedings against GHB distributors and manufacturers. They charged them with labeling and drug violations. The FDA provided expert witnesses who testified as to the serious dangers of GHB. During the trials, the Federal prosecutor and FDA blocked the court's and defense's access to GHB INDs which were represented to "contain no relevant information." The GHB distributors and manufacturers were convicted and sent to prison.
 

mtmon

Member
re:

Have you ever heard of a mislabeled product, because the contents were not properly labeled? It can result in massive fines, total product recalls or the product being pulled until little sticker labels with the correct info being put on the bottles. I'm sure you have seen the sticker label correction at one time or another.

GHB's Day(s) in Court

The FDA's national press release of 8 November 1990, which declared that GHB was a drug, marked the beginning of a series of law-enforcement actions and court cases. At that time, GHB was being sold in health food stores on an over-the-counter basis. With that press release, the FDA and federal and local police began to threaten businesses with legal prosecution for selling GHB. They arrested business owners and told them that they would be prosecuted unless they testified against their wholesale suppliers.

The FDA succeeded in driving the GHB business underground. They began legal proceedings against GHB distributors and manufacturers. They charged them with labeling and drug violations. The FDA provided expert witnesses who testified as to the serious dangers of GHB. During the trials, the Federal prosecutor and FDA blocked the court's and defense's access to GHB INDs which were represented to "contain no relevant information." The GHB distributors and manufacturers were convicted and sent to prison.

PHENIBUT--

Law #
Phenibut is not a controlled substance in the United States, where sales, distribution, and labeling are regulated by FDA rules if it is sold as a dietary supplement.
 

mtmon

Member
re:

Comparison of Phenibut's neuropharmacology to GHB's:

GHB-

Citation: BilZ0r. "Neuropharmacology of Gamma-HydroxyButyrate". Erowid.org, v2 Jan 2004 (v1 June 2003): chemicals/ghb/ghb_pharmacology1.shtml.


γ-Hydroxybutyrate (GHB) is a central nervous system depressant. It has been used as an anxiolytic, anaesthetic and sedative/hypnotic4, inducing a sleep-like state in experimental animals in doses ranging from 0.1 to 1.5g/kg9,5,11. GHB is also a putative neurotransmitter4. Treatment with GHB has been shown to affect many neurotransmitter systems, most notably, dopamine, glutamate and acetylcholine4. A number of early studies focused on GHB's action at dopaminergic synapses and showed that GHB initially inhibits dopamine release and then, time-dependently, causes its release6.
The mechanism of how GHB effects the CNS has been unclear up until now. Resolving the mechanism of GHB's action has been complicated by the fact that GHB acts on both the GABA-B and the newly sequenced GHB receptor4. The evidence that GHB affects the GABA-B receptor is threefold. On a behavioral level, antagonizing the GABA-B receptor stops the discriminative effects of GHB3. On a cellular level, GHB causes a pronounced hyperpolarization of nerve cells and this effect is blocked by GABA-B antagonists but not by GHB receptor antagonists13. Finally, on a molecular level GHB binds (although weakly, KD =100µM10) to the GABA-B receptor.

**As the dose of GHB increases, more and more GHB is binding to, and activating, the inhibitory GABA-B receptor. This leads to the sedative/hypnotic effect of GHB. The selective GHB receptor agonist t-HCA (fig 1) does not cause sedation of any kind, and is presumably a stimulant as it leads to seizures4.

PHENIBUT--(Note the similarities to GHB)

Department of Clinical and Experimental Psychopharmacology, Bekhterev's Psychoneurological Institute, Bekhterev Street, 3, St. Petersburg, 193019, Russia. spbinstb@infopro.spb.su
Abstract
Phenibut (beta-phenyl-gamma-aminobutyric acid HCl) is a neuropsychotropic drug that was discovered and introduced into clinical practice in Russia in the 1960s. It has anxiolytic and nootropic (cognition enhancing) effects. It acts as a GABA-mimetic, primarily at GABA(B) and, to some extent, at GABA(A) receptors. It also stimulates dopamine receptors and antagonizes beta-phenethylamine (PEA), a putative endogenous anxiogenic. The psychopharmacological activity of phenibut is similar to that of baclofen, a p-Cl-derivative of phenibut. This article reviews the structure-activity relationship of phenibut and its derivatives. Emphasis is placed on the importance of the position of the phenyl ring, the role of the carboxyl group, and the activity of optical isomers. Comparison of phenibut with piracetam and diazepam reveals similarities and differences in their pharmacological and clinical effects. Phenibut is widely used in Russia to relieve tension, anxiety, and fear, to improve sleep in psychosomatic or neurotic patients.

ref: Pub Med

GHB is a derivative of GABA and has agonist activity at GABA receptors. Funny, the withdrawal effects are exactly the same in this paper and the last paper -- both involve withdrawal of GABA stimulation.

Loads of similarities to my case:


Comment in:
J Emerg Med. 2001 May;20(4):418-20.

Severe gamma-hydroxybutyrate withdrawal: a case report and literature review.

Craig K, Gomez HF, McManus JL, Bania TC.

Department of Emergency Medicine of St. Luke's-Roosevelt Hospital, New York, New York, USA.


We report a case of gamma-hydroxybutyrate (GHB) withdrawal resulting in severe agitation, mental status changes, elevated blood pressure, and tachycardia hours after stopping chronic use of GHB. The patient admitted to substantial GHB abuse on a daily basis for 2.5 years. Previous attempts at cessation reportedly resulted in diaphoresis, tremors, and agitation. The patient's symptoms, negative polypharmacy history, and negative urine and blood toxicological analysis for alcohol, benzodiazepines, sedative-hypnotics, or other substances suggested the diagnosis of GHB withdrawal. Later analysis of a patient drug sample confirmed the presence of GHB. The patient required 507 mg of lorazepam and 120 mg of diazepam over 90 h to control agitation. This is one of the few reported cases of GHB withdrawal and one of the most severe. Given the increasing use of GHB, more cases of severe GHB withdrawal should be anticipated.
 

mtmon

Member
re:

Here is another article that shows what happens when you overstimulate the GABA system and then remove that stimulation.

1: Neural Plast. 2000;7(1-2):1-8. Related Articles, Links


Long-lasting effects of GABA infusion into the cerebral cortex of the rat.

Montiel T, Almeida D, Arango I, Calixto E, Casasola C, Brailowsky S.

Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico (U.N.A.M.), Mexico. tmontiel@ifisiol.unam.mx

In electrophysiological terms, experimental models of durable information storage in the brain include long-term potentiation (LTP), long-term depression, and kindling. Protein synthesis correlates with these enduring processes. We propose a fourth example of long-lasting information storage in the brain, which we call the GABA-withdrawal syndrome (GWS). In rats, withdrawal of a chronic intracortical infusion of GABA, a ubiquitous inhibitory neurotransmitter, induced epileptogenesis at the infusion site. This overt GWS lasted for days. Anisomycin, a protein synthesis inhibitor, prevented the appearance of GWS in vivo. Hippocampal and neocortical slices showed a similar post-GABA hyperexcitability in vitro and an enhanced susceptibility to LTP induction. One to four months after the epileptic behavior disappeared, systemic administration of a subconvulsant dose of pentylenetetrazol produced the reappearance of paroxysmal activity. The long-lasting effects of tonic GABAA receptor stimulation may be involved in long-term information storage processes at the cortical level, whereas the cessation of GABAA receptor stimulation may be involved in chronic pathological conditions, such as epilepsy. Furthermore, we propose that GWS may represent a common key factor in the addiction to GABAergic agents (for example, barbiturates, benzodiazepines, and ethanol). GWS represents a novel form of neurono-glial plasticity. The mechanisms of this phenomenon remain to be understood.
 
Status
Not open for further replies.

Find the Right Lawyer for Your Legal Issue!

Fast, Free, and Confidential
Top